Abstract
Background
Most previous studies on sleep duration and coronary heart disease (CHD) have been
small and have inadequately controlled for cardiovascular risk factors and chronic
diseases. Therefore, our aim was to prospectively examine the associations of sleep
duration with CHD while accounting for these factors.
Methods
Prospective cohort study of 392 164 adults at age 20 years or older who attended a health check-up program from 1994 to 2011 in Taiwan
and who have information on sleep duration, sleep medications and potential confounders.
Participants answered the question: “How long do you sleep for?”—there were four response
categories: (a) 0–4 h; (b) 4–6 h; (c) 6–8 h and (d) >8 h. The participants were then followed for CHD mortality from the Taiwanese cause-of-death
register.
Results
When compared to those who slept 6–8 h per night, the risk of dying from CHD was increased by 34% (HR 1.34, 95% Confidence
Interval [CI] 0.87–2.07) and 35% (HR 1.35, 95% CI 1.11–1.65) in those who slept less
than 4 h per night and more than 8 h per night, respectively. When stratifying by sex and age, we found some evidence
for a stronger U-shaped association in females than in males and in older adults than
in younger adults (p for interaction = 0.01 and 0.13, respectively).
Conclusions
Adequate sleep duration should be considered an important component of a healthy lifestyle.
Further studies are needed to better elucidate the underlying mechanisms.
Keywords
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Article info
Publication history
Published online: January 06, 2016
Accepted:
January 1,
2016
Received in revised form:
November 28,
2015
Received:
October 19,
2015
Footnotes
☆Statement of authorship: “All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation”.
Identification
Copyright
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
