Ventricular electrical delay at the stimulation site is a fundamental mechanism for
the enhanced cardiac resynchronization therapy (CRT) response in the presence of left
bundle brunch block (LBBB) or more prolonged QRS duration. Several studies have demonstrated
that electrical delay, between the right ventricle (RV) and left ventricle (LV) catheter,
impact the acute hemodynamic response, the reverse LV remodeling, and total mortality
and hospitalizations for worsening of heart failure in patients undergoing CRT [
1
,
2
,
3
,
4
,
5
]. Effective CRT is known to yield LV reverse remodeling at medium term follow-up.
The aim of our study was to evaluate the impact of CRT to dispersion in LV electrical
activation and its relationship to the amount of echocardiographic response to CRT,
in an unselected population of patients with heart failure, left bundle branch block
(LBBB), and sinus rhythm, undergoing first-time CRT. The design of the study (CRT
MORE: Cardiac Resynchronization Therapy Modular Registry; NCT01573091) has been published
previously [
[6]
]. The study protocol was approved by the local institutional Ethics Committee and
all patients provided written informed consent.Keywords
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References
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Article info
Publication history
Published online: March 01, 2016
Accepted:
February 28,
2016
Received:
January 18,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
