Abstract
Background
Epidemiological studies suggest an association between sleep duration and risk of
coronary heart disease, however, the results are controversial. We conducted this
systematic review and meta-analysis to summarize the potential dose-response relationship
between sleep duration and risk of coronary heart disease.
Methods
The electronic reference databases (PubMed and Embase) were searched through January
2016 with selection criteria for relevant studies. Both semiparametric and parametric
methods were used to calculate the pooled risk estimates.
Results
Seventeen articles with 22 independent reports involving 17,841 incident cases of
coronary heart disease among 517,440 participants were included in our meta-analysis.
A U-shaped relationship was detected between sleep duration and risk of coronary heart
disease, with the lowest risk at 7–8 h per day. Compared with 7 h sleep duration per day, the combined relative risk of coronary heart disease were
1.11 (95% CI = 1.05–1.16) for an reduction of 1 h and 1.07 (95% CI = 1.00–1.15) for an increment of 1 h. And the results almost did not change in the subgroup analysis of gender and fatal
cases. Exclusion of any single study did not alter the combined relative risk. In
addition, visual inspection of funnel plots, Begg's and Egger's tests failed to identify
publication bias.
Conclusions
Both short and long sleep durations are significantly associated with increased risk
of coronary heart disease. Compared with 7 h sleep duration per day, the risk of coronary heart disease increases 11% for an
hour decrease and increases 7% for an hour increase.
Abbreviations:
CHD (coronary heart disease), DALYs (disability-adjusted life years), RRs (relative risks), CIs (confidence intervals)Keywords
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Article info
Publication history
Published online: June 15, 2016
Accepted:
June 12,
2016
Received:
May 8,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
