Abstract
Background
This study sought to investigate the optimal percutaneous coronary intervention (PCI)
strategy for true unprotected left main coronary artery (ULMCA) bifurcations.
Methods
The FAILS-2 was a retrospective multi-center study including patients with ULMCA disease
treated with second-generation drug-eluting stents. Of these, we compared clinical
outcomes of a provisional strategy (PS; n = 216) versus an elective two-stent strategy (E2S; n = 161) for true ULMCA bifurcations. The primary endpoint was the incidence of major
adverse cardiac events (MACEs) at 3-years. We further performed propensity-score adjustment
for clinical outcomes.
Results
There were no significant differences between the groups in terms of patient and lesion
characteristics. 9.7% of patients in the PS group crossed over to a provisional two-stent
strategy. MACEs were not significantly different between groups (MACE at 3-year; PS
28.1% vs. E2S 28.9%, adjusted p = 0.99). The rates of target lesion revascularization (TLR) on the circumflex artery
(LCX) were numerically high in the E2S group (LCX-TLR at 3-years; PS 11.8% vs. E2S
16.6%, adjusted p = 0.51).
Conclusions
E2S was associated with a comparable MACE rate to PS for true ULMCA bifurcations.
The rates of LCX-TLR tended to be higher in the E2S group although there was no statistical
significance.
Condensed abstract
This study sought to compare the clinical outcomes of a provisional strategy (PS)
with an elective two-stent strategy (E2S) for the treatment of true unprotected left
main coronary artery bifurcations. 377 Patients (PS 216 vs. E2S 161 patients) were
evaluated, and 9.7% in the PS group crossed over to a two-stent strategy. E2S was
associated with a similar major adverse cardiac event rate at 3-years when compared
to the PS strategy (PS 28.1% vs. E2S 28.9%, p = 0.99). However, the left circumflex artery TLR rate at 3-year tended to be higher
in the E2S group (PS 11.8% vs. E2S 16.6%, p = 0.51).
Abbreviations:
ULMCA (unprotected left main coronary artery), PS (provisional stenting strategy), E2S (elective two-stent strategy), MACEs (major adverse cardiac events), TLR (target lesion revascularization)Keywords
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Article info
Publication history
Published online: October 05, 2017
Accepted:
September 18,
2017
Received in revised form:
August 26,
2017
Received:
May 14,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
