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Ivabradine improves left ventricular twist and untwist during chronic hypertension

  • Mathieu Jozwiak
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Jonathan Melka
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Mario Rienzo
    Affiliations
    AP-HP, Hôpital Européen Georges Pompidou, Service d'Anesthésie-Réanimation Chirurgicale, 75015 Paris, France
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  • Alain Bizé
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Lucien Sambin
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Luc Hittinger
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Alain Berdeaux
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Jin Bo Su
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
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  • Belaid Bouhemad
    Affiliations
    Service d'Anesthésie-Réanimation Chirurgicale, CHU de Dijon, 14 rue Paul Gaffarel, 21079 Dijon, France
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  • Bijan Ghaleh
    Correspondence
    Corresponding author at: INSERM U955 Equipe 03, Faculté de Médecine, 8 rue du Général Sarrail, 94000 Créteil, France.
    Affiliations
    INSERM Unité U955 Equipe 03, 94000 Créteil, France

    Faculté de Médecine, Université Paris-Est, UMR-S U955, 94000 Créteil, France

    Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94000 Maisons-Alfort, France
    Search for articles by this author
Published:November 20, 2017DOI:https://doi.org/10.1016/j.ijcard.2017.11.049

      Abstract

      Background

      Left ventricular (LV) dysfunction develops during LV hypertrophy and particularly during tachycardia. Thus we investigated the effects of heart rate (HR) reduction with ivabradine, an If-channel blocker, on LV twist and untwist which represents myocardial deformation occurring during the overall systole and diastole and therefore provide valuable evaluation of global LV systolic and diastolic function.

      Methods

      Eight chronically instrumented pigs receiving continuous angiotensin II infusion during 28 days to induce chronic hypertension and LV hypertrophy. Measurements were performed at Days 0 and 28 after stopping angiotensin II infusion in the presence and absence of ivabradine.

      Results

      At Day 0, reducing HR from 75 ± 3 to 55 ± 2 beats/min with ivabradine did not affect LV twist but slowed LV untwist along with an increase in LV end-diastolic pressure. At Day 28, LV posterior and septal wall thickness as well as the estimated LV mass increased, indicating LV hypertrophy. LV twist and untwist were significantly reduced by 33 ± 4% from 16 ± 1° and 32 ± 6% from −154 ± 9°/s, respectively, showing global LV systolic and diastolic dysfunction. In this context, ivabradine decreased HR by 25% from 86 ± 5 beats/min and significantly improved LV twist from 11 ± 1 to 14 ± 1° and LV untwist from −104 ± 8 to −146 ± 5°/s.

      Conclusions

      Administration of ivabradine during chronic hypertension and LV hypertrophy improved LV twist and untwist. This further supports the beneficial effect of this drug on both LV systolic and diastolic function during the development of LV hypertrophy.

      Keywords

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