- •Different doses of acute exercise induce specific profiles of circulating microRNAs proposed as biomarkers of heart disease.
- •Circulating microRNAs offer incremental diagnostic value to other cardiac biomarkers in the context of acute exercise.
- •In absence of cardiac damage or dysfunction after acute exercise, circulating microRNAs show “pseudo-disease” signatures.
- •Our results suggest a potential role of circulating microRNAs as mediators of cardiac response to acute exercise.
Translational aspects of the work
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to International Journal of Cardiology
- 72-h kinetics of high-sensitive troponin T and inflammatory markers after marathon.Med. Sci. Sports Exerc. 2011; 43: 1819-1827
- Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches.Physiol. Rev. 2016; 96: 1297-1325
- An endocrine genetic signal between blood cells and vascular smooth muscle cells: role of MicroRNA-223 in smooth muscle function and atherogenesis.J. Am. Coll. Cardiol. 2015; 65: 2526-2537
- Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.J. Clin. Invest. 2014; 124: 2136-2146
- Translating the microRNA signature of microvesicles derived from human coronary artery smooth muscle cells in patients with familial hypercholesterolemia and coronary artery disease.J. Mol. Cell. Cardiol. 2017; 106: 55-67
- Blood-based microRNA signatures differentiate various forms of cardiac hypertrophy.Int. J. Cardiol. 2015; 196: 115-122
- Diagnostic and prognostic value of circulating microRNAs in patients with acute chest pain.J. Intern. Med. 2015; 277: 260-271
- Serum microRNA-1 and microRNA-133a levels reflect myocardial steatosis in uncomplicated type 2 diabetes.Sci. Rep. 2017; 7: 47
- Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs.EMBO Mol. Med. 2012; 4: 1176-1185
- Assessment of microRNAs in patients with unstable angina pectoris.Eur. Heart J. 2014; 35: 2106-2114
- The effect of lifelong exercise dose on cardiovascular function during exercise.J. Appl. Physiol. 2014; 116 (1985): 736-745
- Exercise dose, exercise adherence, and associated health outcomes in the TIGER study.Med. Sci. Sports Exerc. 2014; 46: 69-75
- Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study.Nat. Methods. 2014; 11: 809-815
- Assessing sample and miRNA profile quality in serum and plasma or other biofluids.Methods. 2013; 59: S1-6
- DIANA-miRPath v3.0: deciphering microRNA function with experimental support.Nucleic Acids Res. 2015; 43: W460-466
- Impact of an endurance training program on exercise-induced cardiac biomarker release.Am. J. Physiol. Heart Circ. Physiol. 2015; 308: H913-920
- Cardiac troponin T and I release after a 30-km run.Am. J. Cardiol. 2016; 118: 281-287
- Persistent and reversible cardiac dysfunction among amateur marathon runners.Eur. Heart J. 2006; 27: 1079-1084
- Magnetic resonance imaging of myocardial injury and ventricular torsion after marathon running.Clin. Sci. (Lond.). 2011; 120: 143-152
- Are there deleterious cardiac effects of acute and chronic endurance exercise?.Physiol. Rev. 2016; 96: 99-125
- Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males.Sci. Rep. 2016; 624614
- Histological evidence for reversible cardiomyocyte changes and serum cardiac troponin T elevation after exercise in rats.Phys. Rep. 2016; 4
- Circulating inflammatory miRNA signature in response to different doses of aerobic exercise.J. Appl. Physiol. 2015; 119 (1985): 124-134
- Rapid upregulation and clearance of distinct circulating microRNAs after prolonged aerobic exercise.J. Appl. Physiol. 2014; 116 (1985): 522-531
- Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans.Eur. Heart J. 2010; 31: 659-666
- Clinical significance of cardiac damage and changes in function after exercise.Med. Sci. Sports Exerc. 2008; 40: 1416-1423
- Clinical significance of abnormal electrocardiographic patterns in trained athletes.Circulation. 2000; 102: 278-284
- Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications.J. Am. Coll. Cardiol. 2010; 56: 169-176
- MiRNAs as biomarkers of myocardial infarction: a meta-analysis.PLoS One. 2014; 9e88566
- MiR423-5p as a circulating biomarker for heart failure.Circ. Res. 2010; 106: 1035-1039
- Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training.J. Physiol. 2011; 589: 3983-3994
- Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle.J. Physiol. 2010; 588: 4029-4037
- The endurance athletes heart: acute stress and chronic adaptation.Br. J. Sports Med. 2012; 46: i29-36
- Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1–7).Hypertension. 2011; 58: 182-189
- Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway.Eur. J. Appl. Physiol. 2013; 113: 2473-2486
- Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis.Med. Sci. Sports Exerc. 2012; 44: 1453-1462
- miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.Cell Metab. 2015; 21: 584-595
- Functional screening identifies miRNAs inducing cardiac regeneration.Nature. 2012; 492: 376-381
- Induced pluripotent stem cells: at the heart of cardiovascular precision medicine.Nat. Rev. Cardiol. 2016; 13: 333-349
- Circulating microRNAs as potential biomarkers of aerobic exercise capacity.Am. J. Physiol. Heart Circ. Physiol. 2014; 306: H557-563
☆These authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
☆☆Acknowledgement of grant support: This work was supported in part by the Ministerio de Economía y Competitividad (DEP2012-39262 and DEP2015-69980-P to EI-G and IJCI-2016-29393 to DdG-C), by the Instituto de Salud Carlos III (FIS, PI11/00315 to AD) and European FEDER Funds, and by the Instituto de Salud Carlos III Sara Borrell Grant (CD14/00109 to DdG-C) and Río Hortega Grant (CM16/00128 to LA-R). CIBER Cardiovascular (CB16/11/00403 to DdG-C and VL-C) and CIBER Enfermedades Respiratorias (CB17/06/00021 to LA-R) are projects of the Instituto de Salud Carlos III. The authors declare no conflict of interest.