Highlights
- •Different doses of acute exercise induce specific profiles of circulating microRNAs proposed as biomarkers of heart disease.
- •Circulating microRNAs offer incremental diagnostic value to other cardiac biomarkers in the context of acute exercise.
- •In absence of cardiac damage or dysfunction after acute exercise, circulating microRNAs show “pseudo-disease” signatures.
- •Our results suggest a potential role of circulating microRNAs as mediators of cardiac response to acute exercise.
Abstract
Background
Methods
Results
Conclusions
Translational aspects of the work
Keywords
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Article info
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Footnotes
☆These authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
☆☆Acknowledgement of grant support: This work was supported in part by the Ministerio de Economía y Competitividad (DEP2012-39262 and DEP2015-69980-P to EI-G and IJCI-2016-29393 to DdG-C), by the Instituto de Salud Carlos III (FIS, PI11/00315 to AD) and European FEDER Funds, and by the Instituto de Salud Carlos III Sara Borrell Grant (CD14/00109 to DdG-C) and Río Hortega Grant (CM16/00128 to LA-R). CIBER Cardiovascular (CB16/11/00403 to DdG-C and VL-C) and CIBER Enfermedades Respiratorias (CB17/06/00021 to LA-R) are projects of the Instituto de Salud Carlos III. The authors declare no conflict of interest.