Mitral regurgitation (MR) remains the most common valvular heart disease encountered
in clinical practice. Clinically significant MR results from a diverse range of pathology,
categorized into primary (degenerative) MR resulting from abnormalities of the mitral
valve leaflets or secondary (functional) MR resulting from abnormalities of the left
ventricle (LV) and/or mitral annulus. Patients with primary MR may have leaflet prolapse
with or without a flail segment and can also display concomitant elements of secondary
MR. Pure secondary MR has traditionally been attributed to LV enlargement and dysfunction
that subsequently results in leaflet tenting, mitral annular enlargement and leaflet
malcoaptation [
[1]
]. The mitral annulus, part of the fibrous cardiac skeleton, connects the left atrium
(LA) with the LV and is intimately involved in pathologic conditions that may affect
either of these chambers.To read this article in full you will need to make a payment
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References
- Mitral valve disease—current management and future challenges.Lancet (Lond. Engl.). 2016; 387: 1324-1334
- Predictors of mitral annulus enlargement? A real-time three-dimensional transesophageal study.Int. J. Cardiol. 2018; 270: 349-352
Article info
Publication history
Published online: July 09, 2018
Accepted:
July 6,
2018
Received:
June 29,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
