SARS-CoV-2 inflames the heart. The importance of awareness of myocardial injury in COVID-19 patients

  • Enrico Ammirati
    Corresponding author at: “De Gasperis” Cardio Center and Transplant Center, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.
    Transplant Center and “De Gasperis” Cardio Center, Niguarda Hospital, Milan, Italy
    Search for articles by this author
  • Dao Wen Wang
    Division of Cardiology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Search for articles by this author
      Coronavirus Disease 2019 (COVID-19) is a novel disease caused by the newly discovered coronavirus Severe Acute Respiratory Syndrome (SARS)- Coronavirus (CoV)-2. The main clinical manifestation that leads to hospital admission is the novel coronavirus pneumonia. The latter is characterized by partial filling of air spaces by exudate or transudate, as well as interstitial thickening or partial collapse of the lung alveoli giving the ground-glass opacities, often accompanied by consolidation and vascular enlargement, at CT of the lungs. COVID-19 is recognized worldwide as a major public health issue due to rapid human-to-human transmission [
      • Zhu N.
      • Zhang D.
      • Wang W.
      • Li X.
      • Yang B.
      • Song J.
      • et al.
      A novel coronavirus from patients with pneumonia in China, 2019.
      To read this article in full you will need to make a payment


      Subscribe to International Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Zhu N.
        • Zhang D.
        • Wang W.
        • Li X.
        • Yang B.
        • Song J.
        • et al.
        A novel coronavirus from patients with pneumonia in China, 2019.
        N. Engl. J. Med. 2020; 382 (Epub 2020/01/25) (PubMed PMID: 31978945): 727-733
      1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020. Epub 2020/02/08. doi: (PubMed PMID: 32031570).

        • Cao B.
        • Wang Y.
        • Wen D.
        • Liu W.
        • Wang J.
        • Fan G.
        • et al.
        A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19.
        N. Engl. J. Med. 2020; (Epub 2020/03/19. (PubMed PMID: 32187464))
        • Guo T.
        • Fan Y.
        • Chen M.
        • Wu X.
        • Zhang L.
        • He T.
        • et al.
        Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19).
        JAMA Cardiol. 2020;
        • Shi S.
        • Qin M.
        • Shen B.
        • Cai Y.
        • Liu T.
        • Yang F.
        • et al.
        Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China.
        JAMA Cardiol. 2020;
        • Bratincsak A.
        • El-Said H.G.
        • Bradley J.S.
        • Shayan K.
        • Grossfeld P.D.
        • Cannavino C.R.
        Fulminant myocarditis associated with pandemic H1N1 influenza A virus in children.
        J. Am. Coll. Cardiol. 2010; 55 (Epub 2010/02/16) (PubMed PMID: 20153131): 928-929
        • Hu H.
        • Ma F.
        • Wei X.
        • Fang Y.
        Coronavirus fulminant myocarditis saved with glucocorticoid and human immunoglobulin.
        Eur. Heart J. 2020; (Epub 2020/03/17. (PubMed PMID: 32176300))
        • Inciardi R.M.
        • Lupi L.
        • Zaccone G.
        • Italia L.
        • Raffo M.
        • Tomasoni D.
        • et al.
        Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19).
        JAMA Cardiol. 2020;
        • Deng Q.
        • Hu B.
        • Zhang Y.
        • Wang H.
        • Zhou X.
        • Hu W.
        • et al.
        Suspected myocardial injury in patients with COVID-19: evidence from front-line clinical observation in Wuhan.
        China. Int J Cardiol. 2020;
        • Zhou F.
        • Yu T.
        • Du R.
        • Fan G.
        • Liu Y.
        • Liu Z.
        • et al.
        Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
        Lancet. 2020; (Epub 2020/03/15. (PubMed PMID: 32171076))