Highlights
- •Family history (FH) in first degree relatives is a major risk factor, especially for premature cardiovascular disease (CVD).
- •Data are sparse on FH of differing manifestations of CVD among FDRs of patients with differing manifestations.
- •These data indicate that FH of differing ministrations of CVD produce different risks on different manifestations of CVD.
Abstract
Background
Family history (FH) of cardiovascular disease (CVD) in first degree relatives (FDR)
is a major risk factor, especially for premature events. Data are sparse on FH of
different manifestations of CVD among FDRs of patients with premature myocardial infarction
(MI), chronic stable angina (CSA) or peripheral vascular disease (PVD).
Methods
We obtained FHs from first degree relatives (parents or siblings) of 230 consecutive
patients with premature (men < 60 and women < 65 years) CVD, including 79 wth MI,
39 CSA, 51 PVD and 61 blood donors. Among 1225 parents or siblings, 421 had MI, 222
CSA, 261PVD and 321 were among blood donors.
Results
FH of MI were 5.6% (18/321) among blood donors, 14.0% (59/421) among patients with
premature MI, 14.4% (32/222) CSA, and 8.0% (21/261) PVD. (all p < 0.05). For FH of
CSA the corresponding frequencies were 3.7% 5.2%, 11.3%, and 6.9%. (all p < 0.05).
For PVD, the corresponding frequencies were 2.1%, 3.4%, 0.9% and 0.7%, respectively.
(p = ns).
Conclusions
These data are compatible with the hypothesis that FH of MI, CSA and PVD are significantly
different for patients with premature MI or CSA but not PVD.
Keywords
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Article info
Publication history
Published online: March 15, 2021
Accepted:
March 10,
2021
Received:
July 19,
2020
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
