Highlights
- •E-cigarettes have become a common form of nicotine consumption.
- •Recent studies observed augmented pathologies similar to traditional smoking.
- •Enhanced platelet reactivity in traditional smoking increases ischemic events.
- •Chronic vaping is associated with higher platelet reactivity as compared to traditional smoking and non-smoking.
- •This finding suggests that health effects of vaping might be more severe than previously assumed.
Abstract
Introduction
Vaping emerges as alternative to standard tobacco smoking. However, there is evidence
for critical cardiovascular, gastrointestinal and respiratory side effects. Nevertheless,
long-term vaping effects on thrombocyte reactivity have not been investigated. Therefore,
we investigated the influence of vaping on thrombocyte reactivity in comparison to
standard smoking and non-smoking.
Methods
Platelet function was measured by Multiplate Impedance Aggregometry as area under
the curve (AUC). Smoking habits and characteristics were assessed by questionnaire.
Results were analyzed using inverse probability of treatment weighting (IPTW) and
conventional t-tests to test for robustness.
Results
After IPTW adjustment, participants in all groups were balanced by age, gender, body
height and weight. Collagen-induced aggregation was higher in vapers compared to non-smokers
(non-smokers 52.55 ± 23.97 vs. vapers 66.63 ± 18.96 AUC, p = 0.002) and to smokers (vapers vs. smokers 49.50 ± 26.05 AUC, p < 0.0001). ADP-induced aggregation in vapers was higher compared to non-smokers (non-smokers
33.16 ± 16.61 vs. vapers 45.27 ± 18.67 AUC, p = 0.001) and was numerically increased compared to smokers (vapers vs. smokers 40.09 ± 19.80
AUC, p = 0.08). These findings remained robust in t-test analysis.
Conclusion
This study provides first evidence that vaping leads to enhanced platelet reactivity
compared to standard smoking and non-smoking. This suggests health effects of vaping
might be more severe than previously assumed. Whether this effect translates to clinical
outcome with a higher incidence of major cardiovascular events, should be evaluated
in large-scaled clinical studies.
Keywords
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References
- Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers.J. Am. Coll. Cardiol. 2016; 67: 2802-2803
- Association of cigarette and electronic cigarette use patterns with levels of inflammatory and oxidative stress biomarkers among US adults: population assessment of tobacco and health study.Circulation. 2021; 143: 869-871https://doi.org/10.1161/CIRCULATIONAHA.120.051551
- Impact of smoking on platelet reactivity and clinical outcomes after percutaneous coronary intervention: findings from the ADAPT-DES study.Circ. Cardiovasc. Interv. 2019; 12e007982
- Impact of tobacco versus electronic cigarette smoking on platelet function.Am. J. Cardiol. 2018; 122: 1477-1481
- Acute effects of heat-not-burn, electronic vaping, and traditional tobacco combustion cigarettes: the Sapienza University of Rome-vascular assessment of proatherosclerotic effects of smoking (SUR - VAPES) 2 randomized trial.J. Am. Heart Assoc. 2019; 8e010455
Article info
Publication history
Published online: September 07, 2021
Accepted:
September 2,
2021
Received in revised form:
September 1,
2021
Received:
June 2,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
