LncRNA TUG1 regulates autophagy in atherosclerosis by sponging miR-145-5p

      Zhang et al. [
      • Zhang X.
      • Zai L.
      • Tao Z.
      • Wu D.
      • Lin M.
      • Wan J.
      miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
      ] reported that miR-145-5p is downregulated in blood and arteries specimens of patients with coronary stenosis. CaMKIIδ is promoted by the downregulation of miR-145-5p and then activating autophagy in human aortic vascular smooth muscle cells through the AMPK/mTOR/ULK1 signal pathway to regulate atherosclerosis progress. This finding may recognize a novel target of miR-145-5p in clinical therapy of atherosclerosis, whereas the mechanisms of miR-145-5p lowly expression in myocardial infarction need further exploration.
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