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Arrhythmic mitral annular disjunction syndrome: An underestimated cause of sudden cardiac death

  • Meidina Yeerken
    Affiliations
    Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, China

    Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, China
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  • Ya Wen
    Affiliations
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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  • Huasheng Lv
    Affiliations
    Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, China

    Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, China
    Search for articles by this author
  • Author Footnotes
    1 Drs Lu and Tang contributed equally to this work.
    Baopeng Tang
    Correspondence
    Corresponding authors at: The First Affiliated Hospital of Xinjiang Medical University, No.137, South Liyushan Rd, Xinshi Zone, Urumqi, China.
    Footnotes
    1 Drs Lu and Tang contributed equally to this work.
    Affiliations
    Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, China

    Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, China
    Search for articles by this author
  • Author Footnotes
    1 Drs Lu and Tang contributed equally to this work.
    Yanmei Lu
    Correspondence
    Corresponding authors at: The First Affiliated Hospital of Xinjiang Medical University, No.137, South Liyushan Rd, Xinshi Zone, Urumqi, China.
    Footnotes
    1 Drs Lu and Tang contributed equally to this work.
    Affiliations
    Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, China

    Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, China
    Search for articles by this author
  • Author Footnotes
    1 Drs Lu and Tang contributed equally to this work.
      Mitral valve disease is a common cause of heart failure and death. In the current issue of the Journal, Hasin et al. investigated the pathogenesis of functional mitral regurgitation and found that the reduced left ventricle (LV) rotational movement was independently associated with mitral regurgitation severity [
      • Hasin T.
      • Mann D.
      • Welt M.
      • Barrett O.
      • Shalev A.
      • Godfrey M.
      • Kovacs A.
      • Bogot N.
      • Carasso S.
      • Glikson M.
      • Wolak A.
      Loss of left ventricular rotation is a significant determinant of functional mitral regurgitation.
      ]. This case report has inspired us to investigate mitral annular disjunction (MAD), a syndrome often being misdiagnosed as functional mitral regurgitation at its early stage, and its role in sudden cardiac death (SCD), which has been ignored and underestimated in clinics.

      Keywords

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