Should we be afraid of moderate hyperkalemia in HFrEF outpatients?

Published:October 25, 2022DOI:
      Potassium (K+) is essential for cellular homeostasis and its disturbances are frequent in heart failure (HF) patients, potentially leading to life-threatening conditions. Hyperkalemia has been reported in almost 20% of patients with reduced ejection fraction heart failure (HFrEF) and represents a concern for clinicians, who often opt for therapy down-titration or discontinuation in case of severe hyperkalemia. Current evidence on moderate hyperkalemia is controversial, with a few reports arguing its association with HF therapy discontinuation, especially the reduction of renin-angiotensin-aldosterone system inhibitors (RAASi) dosage, more than with adverse events.
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